Richard B. Buxton

This paper develops a thermodynamic model to show that maintaining the brain's O2/CO2 ratio is critical for energy metabolism, with physiological responses like blood flow changes helping preserve this ratio under various conditions.

The paper connects neural population models to bioenergetic costs by analyzing ATP consumption in neural activity, finding that firing rates correlate with energy use.

The paper measures oxygen consumption across cortical layers in awake mice and finds a decrease in baseline CMRO2 from layer I to IV, accompanied by increased tissue oxygenation.

This paper explores the thermodynamic relationships between neural activity, energy metabolism, and cerebral blood flow, showing that physiological responses align with thermodynamic principles.

The paper demonstrates how additional noninvasive MRI measurements can resolve ambiguities in the BOLD fMRI signal by distinguishing effects of caffeine on blood flow and oxygen metabolism.

This paper tests noninvasive methods to measure absolute cerebral oxygen metabolism (CMRO2) without gas mixtures, finding agreement between new techniques and traditional methods.