Martin Thunemann

This study investigates how trisomy 21 affects oligodendrocyte development and neuron-glia communication in human forebrain assembloids, finding a shift toward a pre-myelinating state and disrupted myelination.

This study examines depth-dependent changes in cerebral oxygenation in Alzheimer's disease models, finding that tau disrupts oxygen levels and that neuronal loss is not due to local hypoxia.

This paper introduces INFORM, a multimodal interface for cortical organoids that enables long-term recordings and modulation of neural activity, revealing functional subnetworks and inhibitory signaling.

The paper introduces dual-mode Bio-CM2, a miniature mesoscope that captures fluorescence and label-free imaging simultaneously, demonstrating its use across different organisms and biological contexts.

This paper introduces blood-mediated optoacoustic stimulation (BOAS) for precise brain cortex stimulation, showing it can trigger neuronal activity comparable to natural visual stimulation and is more efficient than photothermal methods.

Four miniature lenses sharing one CMOS sensor, with computational stitching, give cellular-resolution imaging over 7.5 × 10 mm^2 at video rate, resolving 3,474 mouse cortical neurons.

This paper introduces CLARI-O, a tissue-clearing technique for 3D visualization of cortical organoids and assembloids, enabling structural and functional analysis of cellular interactions and integration in vitro and in vivo.

This study uses FRET-based imaging to measure real-time cGMP levels in arterioles of live mice, showing PDEs affect signaling duration but not amplitude, and ACh does not induce endothelial NO release.

This study uses high-field multinuclear MRI to analyze sodium relaxation heterogeneity in cortical organoids, revealing distinct relaxation components and spatial microenvironment variations.

This paper presents a neurorecording toolkit to longitudinally assess transplanted human cortical organoids in vivo, showing increased neuronal activity and synchronicity over time.

The paper shows that hemodynamic responses in the cortex are influenced by neuromodulators like norepinephrine, with distinct impulse response functions for different neuromodulatory signals.

The paper describes a widefield in vivo imaging system for mesoscopic brain imaging, capable of capturing fluorescent and reflectance signals, and demonstrates its use in awake mice.

The paper shows visual stimulation causes retinotopic acetylcholine release in the mouse visual cortex, indicating organized cholinergic signaling.

This paper describes the construction and use of an adaptive optics two-photon microscope with direct wavefront sensing to improve resolution in deep brain imaging.

The paper uses two-photon calcium imaging and surface electrophysiology to show that only a small fraction of layer 2 neurons follow surface MUA, suggesting MUA may primarily reflect axonal inputs.

The paper demonstrates functional connectivity between human cortical organoids and mouse visual cortex using transparent graphene microelectrodes and two-photon imaging.

The paper measures oxygen consumption across cortical layers in awake mice and finds a decrease in baseline CMRO2 from layer I to IV, accompanied by increased tissue oxygenation.

The paper introduces a synthetic voltage sensor and optogenetic actuator for all-optical electrophysiology in hiPSC-derived neurons, demonstrating its effectiveness in measuring activity across distinct genetic backgrounds.