DNA Damage Response Deficiency Enhances Neuroblastoma Progression and Sensitivity to Combination PARP and ATR Inhibition
Madeline N. Hayes, Sarah Cohen‐Gogo, Lynn Kee, Xueting Xiong, Alex Weiss, Mehdi Layeghifard, Yagnesh Ladumor, Ivette Valencia-Sama, Anisha Rajaselvam, David R. Kaplan, Anita Villani, Adam Shlien, Daniel A. Morgenstern, Meredith S. Irwin
This study shows DDR gene mutations enhance neuroblastoma progression and sensitivity to PARP + ATR inhibitors in zebrafish models and human cells.
Cell Reports · Apr 1, 2025Peer-reviewedCancer Biology