Author

Meredith S. Irwin

University of TorontoORCID 0000-0002-2452-5181Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alex Weiss· 2 shared Ivette Valencia-SamaiD· 2 shared Lynn KeeiD· 2 shared Madeline N. HayesiD· 2 shared Adam ShlieniD· 1 shared Anisha Rajaselvam· 1 shared Anita VillaniiD· 1 shared Daniel A. MorgensterniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Alex Weiss

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Efficacy of RMC-6236 (Daraxonrasib) and novel combination strategies targeting resistance in RAS pathway-driven neuroblastoma

Ivette Valencia-Sama, Lynn Kee, Alex Weiss, Madeline N. Hayes, Michael Ohh, Meredith S. Irwin

This study evaluates RMC-6236 and avutometinib in neuroblastoma models with RAS/MAPK pathway alterations, showing efficacy and identifying combination strategies to overcome resistance.

bioRxiv · Jun 25, 2026 · PreprintCancer Biology

DNA Damage Response Deficiency Enhances Neuroblastoma Progression and Sensitivity to Combination PARP and ATR Inhibition

Madeline N. Hayes, Sarah Cohen‐Gogo, Lynn Kee, Xueting Xiong, Alex Weiss, Mehdi Layeghifard, Yagnesh Ladumor, Ivette Valencia-Sama, Anisha Rajaselvam, David R. Kaplan, Anita Villani, Adam Shlien, Daniel A. Morgenstern, Meredith S. Irwin

This study shows DDR gene mutations enhance neuroblastoma progression and sensitivity to PARP + ATR inhibitors in zebrafish models and human cells.

Cell Reports · Apr 1, 2025Peer-reviewedCancer Biology