Alexander Samir Hatoum

Phenotypic and genetic characterization of different modes of lifetime nicotine use in the All of Us Research Program

The paper identifies genetic risks and phenotypic differences across five nicotine use modes using GWAS in the All of Us Research Program.

Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12

This study identifies time-dependent epistatic interactions between Oprm1 and Fgf12 that modulate opioid-induced locomotion in mice and links Fgf12 to opioid behavior in humans.

Multi-ancestry genome-wide association study and meta-analysis of stimulant use disorder reveals biology and relationships to other psychiatric disorders

This paper conducts a multi-ancestry GWAS of stimulant use disorder, identifies 19 genome-wide significant loci, and finds genetic correlations with other psychiatric and substance use disorders.

Suicidality phenotypes reflect both shared and distinct genetic factors

This study identifies shared and distinct genetic factors underlying suicidality phenotypes using GWAS and structural equation modelling.

Sex-Specific Genetic Architecture and Comorbidities of Alcohol Use Behaviors

This study identifies sex-specific genetic loci and correlations for alcohol use behaviors and their comorbidities using genome-wide association studies.

Multivariate, Multi-omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits

Multi-ancestral genome-wide study of chronic pain reveals widespread genetic correlations with mental and physical health traits

This study performs a genome-wide association study of chronic pain across six ancestries, identifying two significant loci and showing genetic correlations with mental and physical health traits.

A Phenome-Wide Association Study (PheWAS) of Genetic Risk for C-Reactive Protein in Children of European Ancestry: Results From the ABCD Study

This paper identifies childhood phenotypes associated with genetic risk for elevated CRP using a PheWAS in the ABCD Study, finding associations with weight, eating, and screen time that are largely independent of BMI.

Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.

This study performs a multi-ancestral GWAS of DSM-defined nicotine dependence, finding genetic correlations with other substance use disorders and health traits, and identifying a strong general addiction liability factor.

Combining Transdiagnostic and Disorder-Level GWAS Enhances Precision of Psychiatric Genetic Risk Profiles in a Multi-Ancestry Sample

This paper combines transdiagnostic and disorder-level GWAS to enhance genetic risk profiles for psychiatric disorders in multi-ancestry samples, identifying novel SNPs and shared genetic variance.

Two common and distinct forms of variation in human functional brain networks

This paper identifies two distinct forms of variation in human functional brain networks: border shifts and ectopic intrusions, which differ in location, network associations, and behavioral predictions.

GenomeMUSter mouse genetic variation service enables multi-trait, multi-population data integration and analyses

GenomeMUSter integrates and harmonizes mouse genetic variation data across populations to enable multi-trait, multi-population analyses and improve variant-phenotype association studies.

A Multivariate Approach to Understanding the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders

This study uses Genomic Structural Equation Modeling to identify a common genetic factor underlying externalizing phenotypes and substance use disorders, finding that a single dimension of genetic risk best explains their relationships.

Multi-ancestry meta-analysis of tobacco use disorder based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes

This study performs a multi-ancestry meta-analysis of tobacco use disorder using electronic health records, identifying 88 risk loci and 461 potential risk genes, and linking TUD to various health outcomes.

GWAS of Over 427,000 Individuals Establishes GABAergic and Synaptic Molecular Pathways as Key for Cognitive Executive Functions

This study performs a large-scale GWAS on executive functions, identifying genetic variants linked to synaptic and GABAergic pathways and showing distinct genetic relationships with intelligence and psychiatric disorders.

Multi-omics analyses cannot identify true-positive novel associations from underpowered genome-wide association studies of four brain-related traits

The paper shows that multi-omics integration fails to find true-positive novel genes from underpowered GWAS of brain-related traits, highlighting the need for larger sample sizes.

Inferring the Genetic Influences on Psychological Traits Using MRI Connectivity Predictive Models: Demonstration with Cognition

The paper develops fMRI connectivity models to predict intelligence and tests their genetic correlations with measured IQ, finding stronger heritability and genetic overlap compared to single brain regions.

Exploring the genetic overlap of suicide-related behaviors and substance use disorders

The paper examines genetic overlaps between suicide-related behaviors and substance use disorders using GWAS summary statistics and finds significant genetic correlations but little evidence of causation.

Genes identified in rodent studies of alcohol intake are enriched for heritability of human substance use

Childhood Socioeconomic Status and Polygenic Scores for Cognition Have Independent Associations with Cognitive Performance in Childhood

This study shows that childhood socioeconomic status and polygenic scores for cognition independently affect cognitive performance in children, with no interaction between the two factors.

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

This study identifies genetic variants shared between schizophrenia and alcohol use disorder, finding both convergent and divergent effects and evidence of brain tissue expression.

Towards Reproducible Brain-Wide Association Studies

Brain-behaviour correlations in ABCD are tiny (median |r|=0.01), so samples of typical size (N=25) give inflated, irreproducible results; estimates only stabilise around N⪆2,000.

Whole-Cortex Mapping of Common Genetic Influences on Depression and Social Deficits

The paper identifies genetic associations between depression and CU traits in specific brain regions using twin data and neuroimaging.

Genetic and environmental influence on the human functional connectome

The paper examines genetic and environmental influences on the human functional connectome using twin data, finding strong non-shared environmental effects and moderate genetic influence.