Computational design of protein conformational landscapes for metamorphic behavior
Alisa Khramushin, Maddalena Elia, Christian Schellhaas, Alberto Borsatto, Joseph H. Schmidt, Mohamad Yazan Chabaan, Roberta Pierattelli, Kelvin Lau, Francesco Luigi Gervasio, Luciano A. Abriata, Bruno E. Correia
This study designs metamorphic proteins that switch between multiple conformations and shows how mutations can shift their conformational equilibrium.
bioRxiv · Oct 13, 2026 · PreprintSynthetic Biology