Christian Schellhaas

This study designs metamorphic proteins that switch between multiple conformations and shows how mutations can shift their conformational equilibrium.

The paper shows that EMT activates ER-phagy to regulate procollagen secretion, with FAM134A uniquely mediating this process through a non-canonical mechanism.

Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.

This paper improves enzyme engineering by combining active learning and experimental screening to efficiently discover high-performing artificial metalloenzymes.

This study designs soluble analogues of integral membrane proteins using deep learning, achieving high thermal stability and functional accuracy.