HDL regulates TGFβ-receptor lipid raft partitioning, restoring contractile features of cholesterol-loaded vascular smooth muscle cells
Prashanth Thevkar Nagesh, Hitoo Nishi, Shruti Rawal, Tarik Zahr, Joseph M. Miano, Mary G. Sorci‐Thomas, Hao Xu, Naveed Akbar, Robin P. Choudhury, Ashish Misra, Edward A Fisher
This paper shows that cholesterol-loaded vascular smooth muscle cells (VSMCs) lose TGFβ signaling and contractile features, but HDL-mediated cholesterol efflux restores signaling and contractile markers.
bioRxiv · Oct 19, 2023 · PreprintMolecular Biology