ImmunologyThe Journal of ImmunologyPeer-reviewed
Hypoxia-sensing by the Histone Demethylase UTX (KDM6A) Controls Colitogenic CD4+ T cell Fate and Mucosal Inflammation
Mandy I. Cheng, Lee K. Hong, Christian G. Bustillos…·Maureen A. Su
This study shows that UTX, an oxygen-sensitive histone demethylase, modulates colitis severity by affecting CD4+ T cell function and epigenetic regulation under hypoxia.