Maureen A. Su

Xist-mediated gene silencing promotes T cell-driven autoimmunity

This study shows that Xist-mediated gene silencing supports CD4+ T cell persistence and colitogenic capacity, contributing to autoimmunity.

The Histone Methyltransferase KMT2D promotes Natural Killer cell effector molecule release

This study shows that KMT2D promotes effector molecule release in NK cells by regulating H3K4me1 and RAB3D levels, affecting cytotoxicity and cytokine production.

Age-associated Autoimmunity Driven by T cell Immunosenescence

This study identifies age-associated senescent CD4+ T cells as drivers of autoimmunity in CIDP, showing that senolytic and senomorphic therapies can mitigate disease.

TRPV1-cardiac afferent ablation after completed myocardial infarction prevents arrhythmogenic remodeling

This study shows that ablating cardiac TRPV1 afferents after completed myocardial infarction reduces arrhythmogenic remodeling and improves cardiac function.

Paracrine Signals from HIV-1 Infected Immune Cells Reprogram Cervical Cancer Pathways

This study shows HIV-1 infected immune cells alter cervical cancer pathways through paracrine signals, with upregulated PI3K-AKT and interferon-stimulated genes.

UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes

This study identifies UTX's role in regulating progenitor CD8+ T cell fate in T1D by interacting with TCF1 and STAT3, showing its importance in autoimmune diabetes progression.

Polyfunctional IL-21+ IFNg+ T follicular helper cells contribute to checkpoint inhibitor diabetes mellitus and can be targeted by JAK inhibitor therapy

This paper identifies polyfunctional IL-21+ IFNγ+ T follicular helper cells as drivers of ICI-induced diabetes and shows JAK inhibitors can prevent this autoimmune condition.