Single-molecule dissection of CFTR folding defects and pharmacological rescue
Sang Ah Kim, Jesper Levring, Jue Chen, Tae‐Young Yoon
This study uses single-molecule magnetic tweezers to analyze CFTR folding defects and shows pharmacological correctors reshape the folding energy landscape by catalyzing transitions.
Proceedings of the National Academy of Sciences · Mar 31, 2026Peer-reviewedBiophysics