Jue Chen

The paper systematically identifies effector functions of pathogen ORFs across multiple pathways, revealing new roles for known effectors and uncharacterized proteins.

This study uses single-molecule magnetic tweezers to analyze CFTR folding defects and shows pharmacological correctors reshape the folding energy landscape by catalyzing transitions.

This study reports cryo-EM structures of TAP in multiple functional states, revealing how nucleotide-dependent conformational changes drive peptide transport and release.

This study reports cryo-EM structures of TAP inhibited by four viral proteins, revealing a common mechanism to block antigen presentation.

This study determines the cryo-EM structures of MRP2 in three conformational states, revealing its transport mechanism and substrate recognition.

This study presents cryo-EM structures of PKA-C bound to CFTR, revealing mechanisms of phosphorylation and reversible activation through catalytic interactions and conformational flexibility.