Berent Aldikacti

CauloBrowser 2.0: an AI powered update

CauloBrowser 2.0 updates the systems-biology database for Caulobacter crescentus with AI-powered tools for querying and visualizing experimental data.

Stress testing reveals selective vulnerabilities in protein homeostasis

The paper uses transposon sequencing to identify stress-specific vulnerabilities in protein homeostasis by analyzing gene fitness under proteotoxic stresses in bacteria.

Discovering Genetic Modulators of the Protein Homeostasis System through Multilevel Analysis

The paper uses transposon mutagenesis and computational analysis to identify genetic modulators of protein homeostasis in Caulobacter crescentus, finding limited overlap in essential genes across environmental and genetic perturbations.

ATP hydrolysis tunes specificity of a AAA+ protease

The paper shows that ATP hydrolysis rates alter substrate specificity of the AAA+ protease ClpX, affecting its ability to degrade different substrates.

Model-based identification of conditionally-essential genes from transposon-insertion sequencing data

The paper introduces a model-based method to identify conditionally-essential genes using transposon-insertion sequencing data, finding a set of genes essential under specific stress conditions in Caulobacter crescentus.