Peter Chien

CauloBrowser 2.0 updates the systems-biology database for Caulobacter crescentus with AI-powered tools for querying and visualizing experimental data.

The paper shows that activating OxyR in Caulobacter crescentus increases sensitivity to mitomycin C due to collateral effects of antioxidant defenses.

The paper uses transposon sequencing to identify stress-specific vulnerabilities in protein homeostasis by analyzing gene fitness under proteotoxic stresses in bacteria.

The paper uses transposon mutagenesis and computational analysis to identify genetic modulators of protein homeostasis in Caulobacter crescentus, finding limited overlap in essential genes across environmental and genetic perturbations.

This study shows that ssDNA binding and charge changes at DNA binding sites regulate Lon protease activity through allosteric effects and oligomerization.

The paper investigates how Lon protease degradation of FixT affects FixLJ signaling in Caulobacter crescentus, showing that FixT dynamics influence heme biosynthesis but not other Lon-related phenotypes.

This paper uses nanopore sequencing to compare CcrM-dependent DNA methylation in Caulobacter crescentus and Brucella abortus, revealing differences in methylation patterns and regulatory mechanisms.

The paper shows that ATP hydrolysis rates alter substrate specificity of the AAA+ protease ClpX, affecting its ability to degrade different substrates.

The paper introduces a model-based method to identify conditionally-essential genes using transposon-insertion sequencing data, finding a set of genes essential under specific stress conditions in Caulobacter crescentus.

This study identifies FzlA as a regulator linking FtsZ to PG synthesis during bacterial division, showing it activates and spatially orients division-specific PG synthases.