Jared M. Schrader

CauloBrowser 2.0 updates the systems-biology database for Caulobacter crescentus with AI-powered tools for querying and visualizing experimental data.

This paper shows BR-bodies in Brucella regulate RNA stability and virulence by linking phase separation to stress resistance and intracellular fitness.

This study defines the interactions among mycobacterial mRNA degradation enzymes and identifies the functional roles of RNase E's intrinsically disordered regions in degradation processes.

The paper shows bacterial ribonucleoprotein bodies (BR-bodies) maintain an acidic pH environment, enhancing enzyme activity and suggesting pH regulation as a mechanism for RNA processing.

This study identifies CsdA as the first NAD+ cap reader protein in E. coli, showing it binds NAD+ capped RNA and enhances decapping activity.

The paper shows stress causes bacterial BR-bodies to switch from mRNA decay to storage by changing their physical state and function.

This study shows that BR-bodies in Sinorhizobium meliloti enhance mRNA decay efficiency and symbiotic fitness during host colonization.

This paper adapts APEX2 proximity labeling for RNA localization in bacteria, enabling rapid sub-minute labeling and flexible downstream applications.

This study shows BR-bodies in Caulobacter crescentus help the bacteria survive copper stress by changing their structure and protecting enzymes through metal binding.

This study uses Rif-seq to analyze mRNA decay in Caulobacter crescentus, showing global coordination with transcription and translation, and identifies factors influencing mRNA stability.

This study shows that RNase E autoregulation in Caulobacter crescentus involves phase-separation and 5 UTR cleavage, enhancing fitness through proper mRNA decay control.

This study investigates TFIIB's role in transcription termination using yeast, finding increased readthrough and reduced interaction with termination complexes in a TFIIB mutant.

The paper introduces ΔGunfold leaderless, a tool for high-throughput analysis of translation initiation regions (TIRs) and optimization of leaderless mRNAs.

The paper investigates leaderless mRNA translation initiation in bacteria by testing synthetic reporters and develops a computational model to predict initiation efficiency based on mRNA features.

This study uses RNA-Seq to analyze the global transcriptome of Myxococcus xanthus during its multicellular developmental program, revealing gene expression patterns and regulatory networks.

This study identifies RNase E in Caulobacter crescentus as forming liquid-liquid phase separated RNP bodies, similar to eukaryotic P-bodies, which enhance stress response and mRNA degradation.