Gaspar Pinto

Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases

This paper challenges the evolutionary model that the Walker A motif was a seed for early P-loop NTPases by showing that disembodied Walker A peptides do not form stable phosphate-binding nests.

Analysis of Mutations in Precision Oncology using The Automated, Accurate, and User-Friendly Web Tool PredictONCO

PredictONCO is a web tool that predicts the impact of mutations in cancer-related proteins using structural and sequence-based features, achieving high accuracy in variant classification.

A Computational Workflow for Analysis of Missense Mutations in Precision Oncology

This paper presents a bioinformatics pipeline for analyzing missense mutations in oncogenic proteins, providing a probability score for functional impact and suggesting potential FDA/EMA-approved drugs.