Jan Štourač

PredictONCO is a web tool that predicts the impact of mutations in cancer-related proteins using structural and sequence-based features, achieving high accuracy in variant classification.

The paper develops a computational pipeline to annotate functional tunnels in enzyme-ligand complexes and validates it using molecular systems, showing it matches molecular dynamics simulations in speed and accuracy.

This paper presents a bioinformatics pipeline for analyzing missense mutations in oncogenic proteins, providing a probability score for functional impact and suggesting potential FDA/EMA-approved drugs.