Author

Michael T. McMahon

Kennedy Krieger InstituteORCID 0000-0002-8917-7640Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:multiome· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Assaf A. GiladiD· 3 shared Zinia MohantaiD· 2 shared Aimen Al‐HilfiiD· 1 shared Alexander R. BriccoiD· 1 shared Christian T. FarrariD· 1 shared Connor J. GradyiD· 1 shared E. Alejandro Castellanos FrancoiD· 1 shared Iliya MiralavyiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

Assaf A. GiladORCID

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Author profile →

3 papers

Recent·Most cited

Biocatalytic Construction of a CEST MRI Nucleoside Probe: Synthesis and Evaluation of 5-Methyl-5,6-dihydrothymidine

Aimen Al‐Hilfi, E. Alejandro Castellanos Franco, Connor J. Grady, Zinia Mohanta, Michael T. McMahon, Milana Bazayeva, Zhen Li, Kenneth M. Merz, Assaf A. Gilad

This paper describes a biocatalytic method to synthesize 5-MDHT, a CEST MRI probe, and validates its effectiveness using CEST-MRI.

bioRxiv · Jun 25, 2025 · PreprintBiochemistry

The Proton Resonance Enhancement for CEST imaging and Shift Exchange (PRECISE) family of RF pulse shapes for Chemical Exchange Saturation Transfer MRI

Zinia Mohanta, Julia Stabinska, Assaf A. Gilad, Peter B. Barker, Michael T. McMahon

The paper develops a new RF pulse shape for CEST MRI using gradient ascent optimization, showing improved contrast in phantoms and live mice compared to Gaussian and Fermi pulses.

Magnetic Resonance in Medicine · Jan 20, 2025Peer-reviewedBioengineering

Protein Optimization Evolving Tool (POET) based on Genetic Programming

Alexander R. Bricco, Iliya Miralavy, Shaowei Bo, Or Perlman, Christian T. Farrar, Michael T. McMahon, Wolfgang Banzhaf, Assaf A. Gilad

The paper introduces POET, a genetic programming tool for protein optimization, demonstrating its ability to generate proteins with significantly improved MRI contrast and novel functions.

bioRxiv · Mar 5, 2022 · PreprintSynthetic Biology