Author

Kenneth M. Merz

Cleveland ClinicORCID 0000-0001-9139-5893Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1

Frequent Co-Authors

Jian Ping HuiD· 2 shared Majid JafariiD· 2 shared Yao ZhangiD· 2 shared Aimen Al‐HilfiiD· 1 shared Assaf A. GiladiD· 1 shared Connor J. GradyiD· 1 shared Dexin SuiiD· 1 shared E. Alejandro Castellanos FrancoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

Jian Ping HuORCID

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3 papers

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedJun 9, 2026

An N-terminal amphipathic helix governs activity and conformational dynamics of Nramp metal transporters

Majid Jafari, Hongyan Zhao, Yao Zhang…·Jian Ping Hu

This study investigates the role of an N-terminal amphipathic helix in Nramp transporters, showing it regulates conformational dynamics and metal ion transport.

DOI 10.1016/j.jbc.2026.113243

humanstructural biology

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BiochemistrybioRxivPreprintJun 25, 2025

Biocatalytic Construction of a CEST MRI Nucleoside Probe: Synthesis and Evaluation of 5-Methyl-5,6-dihydrothymidine

Aimen Al‐Hilfi, E. Alejandro Castellanos Franco, Connor J. Grady…·Assaf A. Gilad

This paper describes a biocatalytic method to synthesize 5-MDHT, a CEST MRI probe, and validates its effectiveness using CEST-MRI.

DOI 10.1101/2025.06.25.661137

humanexperimental assay

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedNov 7, 2024

Molecular insights into substrate translocation in an elevator-type metal transporter

Yao Zhang, Majid Jafari, Tuo Zhang…·Jian Ping Hu

This study investigates the mechanism of metal substrate translocation in the ZIP transporter BbZIP using structural, biochemical, and computational methods, revealing unique conformational changes and transport dynamics.

12 citations

structural biologyexperimental assay

𝕏 PostBluesky