CCR7+ CD4 T Cell Immunosurveillance Disrupted in Chronic SIV-Induced Neuroinflammation in Rhesus Brain.
Sonny R. Elizaldi, Chase E Hawes, Anil Verma, Ashok Reddy Dinasarapu, Yashavanth Shaan Lakshmanappa, Brent Thomas Schlegel, Dhivyaa Rajasundaram, Jie Li, Blythe P Durbin-Johnson, Zhong-Min Ma, Danielle Beckman, Sean P. Ott, Jeffrey D. Lifson, John H. Morrison, Smita Swaminathan Iyer
The paper identifies CCR7+ CD4 T cells in rhesus brain and border tissues, showing their decline during chronic SIV-induced neuroinflammation and their role in CNS immune surveillance.
bioRxiv · Aug 28, 2023 · PreprintNeuroscience