This study links neuronal population organization disruption to behavioral changes in a macaque model of early-stage Alzheimer's disease and related dementias.

Proceedings of the National Academy of Sciences · Aug 25, 2026Peer-reviewedNeuroscience

CCR7+ CD4 T Cell Immunosurveillance Disrupted in Chronic SIV-Induced Neuroinflammation in Rhesus Brain.

Sonny R. Elizaldi, Chase E Hawes, Anil Verma, Ashok Reddy Dinasarapu, Yashavanth Shaan Lakshmanappa, Brent Thomas Schlegel, Dhivyaa Rajasundaram, Jie Li, Blythe P Durbin-Johnson, Zhong-Min Ma, Danielle Beckman, Sean P. Ott, Jeffrey D. Lifson, John H. Morrison, Smita Swaminathan Iyer

The paper identifies CCR7+ CD4 T cells in rhesus brain and border tissues, showing their decline during chronic SIV-induced neuroinflammation and their role in CNS immune surveillance.

bioRxiv · Aug 28, 2023 · PreprintNeuroscience

CD4 T cell Responses in the CNS during SIV infection

Sonny R. Elizaldi, Anil Verma, Zhong-Min Ma, Sean P. Ott, Dhivyaa Rajasundaram, Mackenzie Leigh Cottrell, Angela D. M. Kashuba, Zandrea Ambrose, Jeffrey D. Lifson, John H. Morrison, Smita Swaminathan Iyer

This study investigates CD4 T cell responses in the CNS during SIV infection in rhesus macaques, revealing their role in viral persistence and immune activation despite ART.

bioRxiv · Aug 24, 2023 · PreprintNeuroscience

Quantitative analysis of synaptic pathology and neuroinflammation: an initial study in a female rhesus monkey model of the “synaptic” phase of Alzheimer’s disease

Danielle Beckman, Kristine Donis‐Cox, Sean P. Ott, Mary Ann Roberts, Lisa Novik, William G.M. Janssen, Eliza Bliss‐Moreau, Peter H. Rudebeck, Mark G. Baxter, John H. Morrison

This study investigates the effects of Aβ oligomers on synaptic pathology and neuroinflammation in a female rhesus monkey model of Alzheimer’s disease, finding significant synaptic loss and inflammatory responses.

bioRxiv · Jan 19, 2018 · PreprintNeuroscience