Jeffrey D. Lifson

A Bispecific Biologic That Robustly Reverses HIV-1 and SIV Latency

This paper develops a bispecific biologic that effectively reactivates HIV-1 and SIV latency in multiple models with minimal off-target effects.

Distinct phases of immune system programming during ART-suppressed immunodeficiency virus infection

The paper identifies two distinct phases of immune system changes in ART-suppressed HIV infection using single-cell transcriptomics and proteomics in rhesus macaques.

Origin and Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following ART Discontinuation

This study identifies the origin and dynamics of viral rebound in SIV-infected macaques after ART discontinuation, showing local tissue replication and systemic expansion of clonal lineages.

Combining a rhesus cytomegalovirus/SIV vaccine with neutralizing antibody to protect against SIV challenge in rhesus macaques

This study shows combining a RhCMV/SIV vaccine with neutralizing antibodies enhances protection against SIV challenge in rhesus macaques.

Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy

This study shows that delivering Env-specific antibodies via AAV prevents SIV rebound in macaques after stopping ART.

Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaques

This study uses single-cell RNA sequencing to analyze microglia and macrophages in rhesus macaques during acute SIV infection, revealing changes in cell clusters and gene expression linked to inflammation and neurodegeneration.

CCR7+ CD4 T Cell Immunosurveillance Disrupted in Chronic SIV-Induced Neuroinflammation in Rhesus Brain.

The paper identifies CCR7+ CD4 T cells in rhesus brain and border tissues, showing their decline during chronic SIV-induced neuroinflammation and their role in CNS immune surveillance.

CD4 T cell Responses in the CNS during SIV infection

This study investigates CD4 T cell responses in the CNS during SIV infection in rhesus macaques, revealing their role in viral persistence and immune activation despite ART.

Sustained IL-15 response signature predicts RhCMV/SIV vaccine efficacy

The paper identifies an IL-15 response signature in vaccinated rhesus macaques that correlates with protection against SIV challenge following RhCMV/SIV vaccination.