Reduced nephron endowment in the common Six2-TGCtg mouse line is due to Six3 misexpression by aberrant enhancer-promoter interactions in the transgene
Alison J. Perl, Han Liu, Matthew R. Hass, Nirpesh Adhikari, Praneet Chaturvedi, Yueh‐Chiang Hu, Rulang Jiang, Yaping Liu, Raphael Kopan
The paper identifies that reduced nephron numbers in Six2-TGCtg mice result from Six3 misexpression due to aberrant enhancer-promoter interactions in the transgene.
Journal of the American Society of Nephrology · Mar 6, 2024Peer-reviewedDevelopmental Biology