Yueh‐Chiang Hu

Loss of Hnf1b in differentiated proximal tubule cells uncovers nephron segment plasticity

This study shows that HNF1B is essential for maintaining proximal tubule identity in mature kidney cells and prevents activation of alternative nephron segment programs.

Constitutive Yap activation in distal nephron segments disrupts epithelial identity and nephron patterning

This study shows that constitutive Yap activation in distal nephron segments disrupts epithelial identity and nephron patterning by altering cell proliferation, lineage boundaries, and gene expression.

Genetic activation of ERK2 recapitulates core neurodevelopmental features of Rasopathy syndromes in mice

This study shows that genetic activation of ERK2 in mice models key neurodevelopmental features of Rasopathy syndromes, including cognitive impairments and facial dysmorphology.

A knock-in Six2Cre line reveals transient interstitial potential in nephron progenitors

The paper generates a knock-in Six2Cre mouse line to study nephron progenitor potential, finding a transient contribution to the renal interstitium around embryonic day 11.

Patient-Specific Midbrain Organoids with CRISPR Correction Recapitulate Neuronopathic Gaucher Disease Phenotypes and Enable Evaluation of Novel Therapies

This paper develops patient-specific midbrain organoids with CRISPR correction to model neuronopathic Gaucher disease and test therapies.

Proximal tubule cells contribute to the thin descending limb of the loop of Henle during mouse kidney development

The paper identifies thin descending limb cells in developing mouse kidneys using scRNA-seq and shows they originate from proximal tubule cells, with Hnf4a playing a role in their development.

Reduced nephron endowment in the common Six2-TGCtg mouse line is due to Six3 misexpression by aberrant enhancer-promoter interactions in the transgene

The paper identifies that reduced nephron numbers in Six2-TGCtg mice result from Six3 misexpression due to aberrant enhancer-promoter interactions in the transgene.

ATF7IP2/MCAF2 directs H3K9 methylation and meiotic gene regulation in the male germline

This study identifies ATF7IP2 as a critical regulator of H3K9 methylation and meiotic gene regulation in male germline, showing its role in heterochromatin organization and meiotic sex chromosome inactivation.

Hedgehog signaling is required for the maintenance of mesenchymal nephron progenitors

This study identifies Hedgehog signaling as critical for maintaining mesenchymal nephron progenitors by inhibiting Notch signaling and upregulating Fox factors.

MiR-324-5p regulates the structure of dendritic spines and is essential for hippocampal long-term potentiation

This study shows that miR-324-5p regulates dendritic spine structure and hippocampal long-term potentiation in mice by affecting synaptic proteins and plasticity.

A SNP affects Wnt4 expression in endometrial stroma, with antagonistic implications for pregnancy, endometriosis and reproductive cancers

This study identifies a SNP that affects Wnt4 expression in endometrial stroma, linking it to pregnancy, endometriosis, and reproductive cancers through differential gene regulation.

Endogenous retroviruses drive species-specific germline transcriptomes in mammals

This study identifies endogenous retroviruses as drivers of species-specific germline transcriptomes in mammals, particularly through their role in gene activation and enhancer function in spermatogenesis.

Genomic structure, evolutionary origins, and reproductive function of a large amplified intrinsically disordered protein gene on the X chromosome (Laidx) in mice.

The paper identifies a large amplified intronless gene, Laidx, on the X chromosome in mice, shows its evolutionary origin from a horizontal gene transfer, and finds no reproductive defects in its absence.

Use of CRISPR/Cas9 Gene Targeting to Conditionally Delete Glucocorticoid Receptors in Rat Brain

This study uses CRISPR/Cas9 to create a conditional GR knockout in rats, showing sex-specific behavioral effects of GR deletion in the prelimbic cortex.