Raphael Kopan

This study uses single-cell RNA sequencing in rhesus macaques to identify transitional states and signaling shifts in nephron progenitor cells during late gestation, suggesting a mechanism for lateral branch nephrogenesis.

This paper shows that Notch dimerization is essential for vascular integrity and that NDD mice exhibit environmental sensitivity and vascular defects.

This paper describes a method to integrate collecting systems in kidney organoids by fusing distal nephron with ureteric bud tissues, enabling functional nephrons with continuous epithelial lumens.

The paper shows that Notch dimerization is crucial for intestinal homeostasis, with HDAC2 activity modulating Notch function in intestinal stem cells.

The paper identifies that reduced nephron numbers in Six2-TGCtg mice result from Six3 misexpression due to aberrant enhancer-promoter interactions in the transgene.

This study identifies the unique role of Runx1 in skeletal muscle differentiation and regeneration through its ETS interaction domain, distinguishing it from Runx2.

The paper investigates Notch signaling's role in nephron segmentation, finding it promotes proximal fate selection while not affecting distal fate in mouse and human kidney development.

The paper shows age-dependent changes in nephron progenitor translation and signaling that influence nephrogenesis timing, with Tsc1 affecting Wnt signaling balance.

The paper shows that enhancers with SPS sites are more resistant to repression by Hairless co-repressor compared to those with CSL sites.

This study shows that Runx1 deletion in mK4 cells leads to widespread chromatin and gene expression changes, with indirect effects mediated by Zeb2.

The paper shows that an enhancer with specific binding sites can induce Notch haploinsufficiency phenotypes in Drosophila with wild-type Notch gene dose by promoting rapid Notch turnover through a bind and discard mechanism.

This study shows Jag1 modulates oscillatory Dll1-Notch-Hes1 signaling in pancreatic progenitors to coordinate their growth and fate, with Jag1 also specifying most bipotent progenitors.

This study shows that Notch dimerization is critical for intestinal homeostasis and immune responses, with mite infestation worsening related phenotypes and triggering lymphoma in mutant mice.