KRAS Inhibition Reverses Chemotherapy Resistance Promoted by Therapy-Induced Senescence-like in Pancreatic Ductal Adenocarcinoma
Analía Meilerman Abuelafia, Patricia Santofimia‐Castaño, Matías Estarás, Daniel Grasso, Eduardo Chuluyán, Gwen Alyce Lomberk, Raul A. Urrutia, Nelson Dusetti, Nicolas Alejandro Fraunhoffer, Juan Iovanna
This study shows that KRAS inhibition can reverse chemotherapy resistance in PDAC by targeting therapy-induced senescence-like cells, with ERK pathway involvement.
Translational Oncology · May 17, 2025Peer-reviewedCancer Biology