Widespread detection of Polyethylene glycol reveals chronic human exposure through pharmaceutical drugs
Harsha Gouda, Patricia Kelly, Luke Whiley, Daniel Gómez‐Pérez, Anna Mascellani Bergo, Wilhan Donizete Gonçalves Nunes, Elena Chekmeneva, Ada H. Y. Yuen, Mark David, Shona Mckirdy, Andrew Nelson, Darren L. Smith, Haoqi Nina Zhao, Jeong In Seo, Edward J. Mathias, , Pieter C. Dorrestein
Polyethylene glycol in human biofluids can mark drug exposure rather than contamination; it is oxidized to acid metabolites and appears in 2.3% of public metabolomics files.
bioRxiv · Sep 18, 2026 · PreprintBiochemistry✦ In-depth digest