Andrew Nelson

Polyethylene glycol in human biofluids can mark drug exposure rather than contamination; it is oxidized to acid metabolites and appears in 2.3% of public metabolomics files.

This study investigates the structural and functional properties of BrxC, a conserved AAA+ ATPase in the BREX phage restriction system, revealing its role in mediating competing protein associations and DNA binding that regulate host methylation and phage restriction.

The paper reprocesses SARS-CoV-2 genomic data to correct systematic errors in phylogenies using a novel assembly tool, resulting in a cleaner global tree of 4.47 million samples.

This study identifies and characterizes the PglZ:BrxB sub-complex of BREX phage defence systems, revealing PglZ as a metal-dependent nuclease that contributes to phage defence.

The paper identifies Clostridium species that metabolize human milk oligosaccharides, producing beneficial metabolites and suppressing inflammation and pathogen growth in preterm infants.

The paper characterizes the BREX system in Salmonella, determines the structure of PglX, and shows how rational engineering expands phage targeting and host motif methylation.

This study adjusts for sampling bias in SARS-CoV-2 Ct values and finds that viral variant and age affect within-host viral burdens, with variant effects varying by vaccination status.