Author

Darren L. Smith

Northumbria University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:database / resource· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Andrew NelsoniD· 2 shared Abigail KellyiD· 1 shared Ada H. Y. Yuen· 1 shared Alex J Kaiser· 1 shared Anna Mascellani Bergo· 1 shared Barry L. StoddardiD· 1 shared Brett K. KaiseriD· 1 shared Christopher QuinceiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Andrew NelsonORCID

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Author profile →

2 papers

Recent·Most cited

Widespread detection of Polyethylene glycol reveals chronic human exposure through pharmaceutical drugs

Harsha Gouda, Patricia Kelly, Luke Whiley, Daniel Gómez‐Pérez, Anna Mascellani Bergo, Wilhan Donizete Gonçalves Nunes, Elena Chekmeneva, Ada H. Y. Yuen, Mark David, Shona Mckirdy, Andrew Nelson, Darren L. Smith, Haoqi Nina Zhao, Jeong In Seo, Edward J. Mathias, , Pieter C. Dorrestein

Polyethylene glycol in human biofluids can mark drug exposure rather than contamination; it is oxidized to acid metabolites and appears in 2.3% of public metabolomics files.

bioRxiv · Sep 18, 2026 · PreprintBiochemistry✦ In-depth digest

Competing forms of protein-protein association and DNA binding exhibited by BrxC from the BREX phage restriction system

Alex J Kaiser, Jennifer J. Readshaw, Lindsey Doyle, Maria Puiu, Abigail Kelly, Sydney F. McGuire, Julieta Peralta Acosta, Duc Vu, Andrew Nelson, Darren L. Smith, Lidia Araújo‐Bazán, Ernesto Arias‐Palomo, Yvette A. Luyten, Barry L. Stoddard, Tim R. Blower, Brett K. Kaiser

This study investigates the structural and functional properties of BrxC, a conserved AAA+ ATPase in the BREX phage restriction system, revealing its role in mediating competing protein associations and DNA binding that regulate host methylation and phage restriction.

bioRxiv · Apr 11, 2026 · PreprintBiochemistry