Author

Shannon A. Bainbridge

University of OttawaORCID 0000-0002-8947-8152Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Abolfazl Nik-AkhtariD· 3 shared Yusmaris CariacoiD· 3 shared Fahmida Jahan· 2 shared Keir J. MenziesiD· 2 shared Alex Green· 1 shared Goutham VasamiD· 1 shared Jacob Ouellet· 1 shared Jessica PudwelliD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMolecular Biology

Abolfazl Nik-AkhtarORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PARP1/2-linked ADP-ribosylation impairs trophoblast mitochondrial respiration in a TNF-α model of inflammation-mediated preeclampsia.

Abolfazl Nik-Akhtar, Sophia Vanegas Pineda, Jacob Ouellet, Fahmida Jahan, Yusmaris Cariaco, Keir J. Menzies, Shannon A. Bainbridge

This study shows PARP1/2-linked ADP-ribosylation impairs trophoblast mitochondrial respiration in inflammation-mediated preeclampsia, with olaparib improving respiration.

bioRxiv · Oct 21, 2026 · PreprintCell Biology

Prenatal fentanyl and Δ9-tetrahydrocannabinol exposure disrupt placental function and fetal growth in a mouse model of multidrug use

Yusmaris Cariaco, Nikita Larionov, Abolfazl Nik-Akhtar, Jessica Pudwell, Kira King, Laura Gaudet, Shannon A. Bainbridge

This study shows that prenatal exposure to fentanyl and THC in mice impairs placental function and causes fetal growth restriction, with the greatest effects seen when both drugs are used together.

bioRxiv · Sep 18, 2026 · PreprintMolecular Biology

NAD+ depletion and altered mitochondrial function are key to the establishment of placental dysfunction in an inflammatory-driven subclass of preeclampsia

Fahmida Jahan, Goutham Vasam, Yusmaris Cariaco, Abolfazl Nik-Akhtar, Alex Green, Keir J. Menzies, Shannon A. Bainbridge

Boosting NAD+ levels prevent inflammatory-driven preeclampsia by improving placental mitochondrial function.

bioRxiv · Sep 9, 2023 · PreprintMolecular Biology