Author

Cheng Tan

RIKEN Center for Computational ScienceORCID 0000-0002-8957-4267Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1 Assay:electronic health records· 1

Frequent Co-Authors

Yuji SugitaiD· 3 shared Azuki MizutaniiD· 2 shared Jaewoon JungiD· 2 shared Shoji TakadaiD· 2 shared Chenyang GuiD· 1 shared Giovanni Bruno BrandaniiD· 1 shared Hiroshi OchiaiiD· 1 shared Soundhararajan GopiiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

Yuji SugitaORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Hero11 Unlocks TDP-43 Condensate Fluidity via Targeting Inter-Helical Interactions

Cheng Tan, Jaewoon Jung, Yuji Sugita

This study shows Hero11 disrupts TDP-43 condensate structure by targeting helix-helix interactions, altering condensate fluidity and dynamics.

bioRxiv · May 11, 2026 · PreprintBiochemistry

Heterogenous organization in condensates of multiple transcription factors in embryonic stem cells

Azuki Mizutani, Cheng Tan, Yuji Sugita, Shoji Takada

This study uses molecular dynamics simulations to analyze the heterogeneous behavior of condensates formed by four master transcription factors in embryonic stem cells, revealing distinct roles for each factor in condensate formation.

Biophysical Journal · Apr 8, 2025Peer-reviewedBiophysics

In silico nanoscope to study the interplay of genome organization and transcription regulation

Soundhararajan Gopi, Giovanni Bruno Brandani, Cheng Tan, Jaewoon Jung, Chenyang Gu, Azuki Mizutani, Hiroshi Ochiai, Yuji Sugita, Shoji Takada

The paper develops a multiscale modeling pipeline to simulate chromatin organization and transcription regulation in mouse embryonic stem cells, revealing how sequence-regulated accessibility facilitates enhancer-promoter communication.

Nucleic Acids Research · Mar 7, 2025Peer-reviewedMolecular Biology

FoldToken3: Fold Structures Worth 256 Words or Less

Zhangyang Gao, Cheng Tan, Stan Ziqing Li

FoldToken3 compresses protein structures into 256 tokens or less while maintaining reconstruction quality comparable to FoldToken2.

bioRxiv · Jul 8, 2024 · PreprintMolecular Biology