Yuji Sugita

This study shows that enzymes in biomolecular condensates enhance catalytic activity through crowding-induced conformational changes and enable increased mobility despite environmental viscosity.

This study determines the cryo-EM structure of SfApuR2, an ultraviolet-sensitive anion-conducting rhodopsin, and identifies structural features that explain its UV sensitivity and gating mechanism.

This study identifies CAMSAP2 condensates as a γ-TuRC-independent mechanism for non-centrosomal microtubule nucleation through phase separation and tubulin organization.

This study shows Hero11 disrupts TDP-43 condensate structure by targeting helix-helix interactions, altering condensate fluidity and dynamics.

This paper reports high-resolution structures of kinesin-14 motor proteins during different mechanochemical states, revealing structural transitions that drive force generation and the power stroke.

CGBack uses a diffusion model to accurately backmap coarse-grained molecular systems to all-atom structures, improving upon existing methods by preserving stereochemistry and handling complex systems.

The paper investigates the γ-subunit rotation mechanism in F1-ATPase using cryo-EM structures and molecular dynamics simulations, proposing the distortion-push mechanism.

This study uses molecular dynamics simulations to show that glycosylation modulates protein surfaces through both local shielding and long-range allosteric effects.

The paper shows Atg1 phosphorylates Atg2 to enable lipid transport for autophagosome formation in yeast.

ColBuilder generates atomistic models of crosslinked collagen fibrils and validates them through molecular dynamics simulations.

This study uses molecular dynamics simulations to analyze the heterogeneous behavior of condensates formed by four master transcription factors in embryonic stem cells, revealing distinct roles for each factor in condensate formation.

The paper develops a multiscale modeling pipeline to simulate chromatin organization and transcription regulation in mouse embryonic stem cells, revealing how sequence-regulated accessibility facilitates enhancer-promoter communication.

This paper designs and characterizes α-helical peptide channels with specific stoichiometry and conductance properties through computational and experimental methods.