Jaewoon Jung

Hero11 Unlocks TDP-43 Condensate Fluidity via Targeting Inter-Helical Interactions

This study shows Hero11 disrupts TDP-43 condensate structure by targeting helix-helix interactions, altering condensate fluidity and dynamics.

The distortion-push mechanism for the γ-subunit rotation in F1-ATPase

The paper investigates the γ-subunit rotation mechanism in F1-ATPase using cryo-EM structures and molecular dynamics simulations, proposing the distortion-push mechanism.

ColBuilder: Flexible structure generation of crosslinked collagen fibrils

ColBuilder generates atomistic models of crosslinked collagen fibrils and validates them through molecular dynamics simulations.

In silico nanoscope to study the interplay of genome organization and transcription regulation

The paper develops a multiscale modeling pipeline to simulate chromatin organization and transcription regulation in mouse embryonic stem cells, revealing how sequence-regulated accessibility facilitates enhancer-promoter communication.

De novo design of α-helical peptide channels with designer stoichiometry

This paper designs and characterizes α-helical peptide channels with specific stoichiometry and conductance properties through computational and experimental methods.