Chenyang Gu

This paper introduces a physics-based model to simulate chromatin domain dynamics driven by epigenetic factors, revealing that nucleosome-nucleosome interactions shape genomic organization.

The paper develops a multiscale modeling pipeline to simulate chromatin organization and transcription regulation in mouse embryonic stem cells, revealing how sequence-regulated accessibility facilitates enhancer-promoter communication.

This paper introduces Hi-C metainference, a Bayesian method to model chromatin organization, revealing that gene loci in mouse embryonic stem cells are dynamically condensed and organized as crumpled globules.