This study maps cis and trans meQTLs in cattle blood DNA methylation using EpiChip data, identifying regulatory genes and hotspots associated with methylation patterns.

bioRxiv · Jul 8, 2026 · PreprintGenetics

Heat Stress Induces Locus-Specific DNA Hypomethylation Linked to Immune Regulation in Lactating Holstein Cows

Gabriel Costa Monteiro Moreira, Alexis Ruíz-González, Melodie Joigner, Valentin Costes, Aurélie Chaulot‐Talmon, Francesca Ali, Lorraine Bourgeois‐Brunel, Hélène Jammes, Daniel E. Rico

This study identifies heat stress-induced DNA hypomethylation in dairy cows' blood methylome, affecting immune-related regulatory regions and genes.

bioRxiv · Mar 26, 2026 · PreprintGenomics

The RUMIGEN EpiChip: a versatile, medium density DNA methylation Beadchip for large scale population studies in cattle

Valentin Costes, Adrián López Catalina, Amrita Raja Ravi Shankar, Gabriel Costa Monteiro Moreira, Sophie Martel, Ludivine Lietar, Carmen Garcia Alba, Javier López Viana, Aurélie Chaulot‐Talmon, Francesca Ali, Christine Couldrey, Mekki Boussaha, Sébastien Fritz, Eveline Mengwi Ibeagha-Awemu, Nathalie Bissonnette, , Hélène Kiefer

The paper introduces the RUMIGEN EpiChip, a DNA methylation array for cattle, demonstrating its utility in studying phenotypic variation and age prediction through methylation analysis.

bioRxiv · Dec 22, 2025 · PreprintGenomics

The effect of environmental enrichment on immune cell DNA methylation profiles depends on the parity of sows.

Mariana Mescouto Lopes, Gabriel Costa Monteiro Moreira, Aurélie Chaulot‐Talmon, Anne Frambourg, Valentin Costes, Julie Demars, Élodie Merlot, Hélène Jammes

This study identifies DNA methylation changes in sows related to parity and environmental enrichment, suggesting epigenetic adaptation and potential biomarkers for affective states.

bioRxiv · Jul 1, 2025 · PreprintGenomics

Unveiling Inter-Embryo Variability in Spindle Length over time: towards Quantitative Phenotype Analysis.

Yann Le Cunff, Laurent Chesneau, Sylvain Pastezeur, Xavier Pinson, Nina Soler, Danielle Fairbrass, Benjamin Mercat, Ruddi Rodríguez-García, Zahraa Alayan, Ahmed Abdouni, Gary de Neidhardt, Valentin Costes, Mélodie Anjubault, Hélène Bouvrais, Christophe Héligon, Jacques Pécréaux

The paper identifies three archetypes of spindle elongation in C. elegans embryos that capture most inter-individual variability, revealing that only three independent mechanisms drive spindle elongation across conditions.

PLoS Computational Biology · Sep 5, 2024Peer-reviewedBioinformatics