Sylvain Pastezeur

Microtubule stiffening by doublecortin-domain protein ZYG-8 contributes to mitotic spindle orientation during zygote division in Caenorhabditis elegans.

This study shows that ZYG-8 increases microtubule rigidity, which is essential for proper spindle orientation during C. elegans zygote division, and links microtubule mechanics to spindle positioning.

Semi supervised GAN for smart microscopy, fast and data efficient cell cycle classification

The paper introduces a semi-supervised GAN for cell cycle classification using limited annotated data and unlabelled microscopy images, achieving high accuracy on the Mitocheck dataset.

Unveiling Inter-Embryo Variability in Spindle Length over time: towards Quantitative Phenotype Analysis.

The paper identifies three archetypes of spindle elongation in C. elegans embryos that capture most inter-individual variability, revealing that only three independent mechanisms drive spindle elongation across conditions.

Dynein dynamics at the microtubule plus-ends and cortex during division in the C. elegans zygote

The paper investigates dynein dynamics during C. elegans zygote division, finding that dynein accumulates at microtubule plus-ends and cortex, with posterior enrichment contributing to force imbalance and polarity.

The mitotic spindle in the one-cell C. elegans embryo is positioned with high precision and stability

The paper quantifies the precision and stability of mitotic spindle positioning in C. elegans embryos and proposes a mechanism involving microtubule buckling.