This study shows that periodic miRNA synthesis can more effectively repress target RNA than constant synthesis, with optimal frequency-dependent repression.

Nucleic Acids Research · Aug 21, 2025Peer-reviewedBiophysics

Mammalian cell characterisation by non-invasive plate reader assay

Alice Grob, Chiara Enrico Bena, Roberto Di Blasi, Daniele Pessina, Matthew Sood, Zhou Yunyue, Carla Bosia, Mark Isalan, Francesca Ceroni

This paper develops a non-invasive plate reader assay for high-throughput mammalian cell analysis, showing its applicability to different cell lines and conditions.

Nature Communications · Jan 2, 2024Peer-reviewedSynthetic Biology

OmniReprodubileCellAnalysis: a comprehensive toolbox for the analysis of cellular biology data.

Dora Tortarolo, Simone Pernice, Fabiana Clapero, Donatella Valdembri, Guido Serini, Federica Riccardo, Lidia Tarone, Chiara Enrico Bena, Carla Bosia, Sandro Gepiro Contaldo, Marco Beccuti, Marzio Alfio Pennisi, Francesca Cordero

The paper introduces ORCA, an open-source Shiny application for semi-automated analysis of cellular biology experiments, promoting reproducibility and open science practices.

IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · Dec 5, 2023Peer-reviewedBioinformatics