Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs
Meng Zhang, Miao Gui, Zifu Wang, Christoph Gorgulla, James J. Yu, Hao Wu, Zhen-Yu Jim Sun, Christoph Klenk, L. Merklinger, Lena Morstein, Franz Hagn, Andreas Plückthun, Alan Brown, Mahmoud Lotfi Nasr, Gerhard Wagner
The paper reports cryo-EM structures of a GPCR-G protein complex in lipid nanodiscs, revealing structural insights into G protein activation without stabilizing agents.
Nature Structural & Molecular Biology · Feb 25, 2021Peer-reviewedMolecular Biology