Gerhard Wagner

This study identifies the structural basis of UIS2-mediated eIF2α dephosphorylation in Plasmodium using integrated modeling and shows how Salubrinal inhibits this process.

This study identifies how nanoprotrusions enlarge along paths of least resistance to form cytocapsular tubes, driving metastasis initiation and branching in human tissues.

This paper identifies UIS2 as a critical phosphatase for Plasmodium proliferation during the erythrocytic stage and reveals its structural mechanism for eIF2alpha dephosphorylation, suggesting it as a target for antimalarial drugs.

AdaptiveFlow enables large-scale virtual screening of 69 billion molecules to discover validated FSP1 inhibitors, improving efficiency and scalability in drug discovery.

The paper reports cryo-EM structures of a GPCR-G protein complex in lipid nanodiscs, revealing structural insights into G protein activation without stabilizing agents.