Zhen-Yu Jim Sun

The paper introduces molecular COUPLrs to systematically target protein complexes, identifying new glue classes and their interactions in cancer cell lines.

The paper identifies lithocholic acid as a bile acid metabolite that modulates circadian rhythms in intestinal cells by affecting core clock proteins and feedback loops.

The paper uses proteomics data and machine learning to identify protein signatures distinguishing renal cell carcinomas from normal tissues and different subtypes.

This study investigates the DNA-binding mechanism of BCL11A, revealing the role of ZnF6 in repression of {gamma}-globin gene expression and its implications for therapeutic design.

This paper identifies a non-enzymatic HDAC inhibitor with anti-tumor and anti-psychedelic effects, showing reduced gene modulation compared to enzymatic inhibitors.

The paper reports cryo-EM structures of a GPCR-G protein complex in lipid nanodiscs, revealing structural insights into G protein activation without stabilizing agents.