Author

Cole R. K. Harder

University of California, Santa CruzORCID 0000-0002-8967-9114Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:mouse· 1

Frequent Co-Authors

Aditya DendukuriiD· 1 shared Aidan L. Morson· 1 shared Alex SpaethiD· 1 shared Ali FathiiD· 1 shared Andreas R. HierlemanniD· 1 shared Andrew J. PeterseniD· 1 shared Anita BhattacharyyaiD· 1 shared Bradley M. ColquittiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Aditya DendukuriORCID

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2 papers

Recent·Most cited

Protosequences in brain organoids model intrinsic brain states

Tjitse van der Molen, Alex Spaeth, Mattia Chini, Sebastian Hernandez, Gregory A. Kaurala, Hunter E. Schweiger, Cole Duncan, Sawyer McKenna, Jinghui Geng, Max Lim, Julian Bartram, Tobias Gänswein, Aditya Dendukuri, Zongren Zhang, Jesus Gonzalez-Ferrer, , Tal Sharf

This study shows that structured firing sequences emerge in human and murine brain organoids and neonatal brain slices, suggesting innate rather than experience-dependent neural coding.

Nature Neuroscience · Nov 24, 2025Peer-reviewedNeuroscience

Chemically Induced Senescence in Human Stem Cell-Derived Neurons Promotes Phenotypic Presentation of Neurodegeneration

Ali Fathi, Sakthikumar Mathivanan, Linghai Kong, Andrew J. Petersen, Cole R. K. Harder, Jasper Block, Julia M. Miller, Anita Bhattacharyya, Daifeng Wang, Su‐Chun Zhang

The paper develops a chemical cocktail to induce senescence in iPSC-derived neurons to better model age-related neurodegenerative disorders.

Aging Cell · Dec 24, 2021Peer-reviewedNeuroscience