Tal Sharf

Multiscale Cloud-based Pipeline for Neuronal Electrophysiology Analysis and Visualization

The paper presents a cloud-based pipeline for analyzing and visualizing neuronal electrophysiology data from HD-MEAs, demonstrating its utility in simplifying data analysis and understanding neural activity.

Spatially defined axonal guidance in neural organoids with micropatterned microfluidic channels

This paper introduces a microfluidic platform called directoids to study directional axonal growth between neural organoids, showing robust directional bias in axon outgrowth.

SpikeLab: Agentic tools for spike data analysis

SpikeLab is a text-to-analysis framework for neural spike data that ensures correct and reproducible results using agentic systems, outperforming other models in a controlled benchmark.

Self-Organizing Neural Networks in Organoids Reveal Principles of Forebrain Circuit Assembly

This study uses mouse forebrain organoids to show how variations in cellular composition influence the self-organization of neural circuits, revealing intrinsic principles of forebrain circuit assembly.

Goal-Directed Learning in Cortical Organoids

This study demonstrates goal-directed learning in cortical organoids using a closed-loop electrophysiology framework and artificial reinforcement learning.

Protosequences in brain organoids model intrinsic brain states

This study shows that structured firing sequences emerge in human and murine brain organoids and neonatal brain slices, suggesting innate rather than experience-dependent neural coding.

Incubator-Free Organoid Culture in a Sealed Recirculatory System

This paper introduces a sealed recirculatory system for organoid culture that eliminates the need for CO2 incubators and enables continuous live imaging and metabolic viability.

Distinct Synaptic Mechanisms Drive NRXN1 Variant-Mediated Pathogenesis in iPSC-Derived Neuronal Models of Autism and Schizophrenia

This study compares synaptic effects of NRXN1 deletions in ASD and SCZ iPSC models, finding distinct synaptic and network impairments in ASD.

A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring

This paper introduces an automated brain organoid platform with IoT integration for continuous monitoring and control, showing increased neural activity and stable firing rates during automated media exchange.

Pathological microcircuits and epileptiform events in patient hippocampal slices

The paper uses high-density electrophysiology to study epileptiform activity in human hippocampal slices from epilepsy patients, revealing unexpected network oscillations in dentate gyrus slices.

Human brain organoid networks

This study uses high-density electrode arrays to analyze neural activity in human brain organoids, revealing functional connectivity patterns and responses to benzodiazepine treatment.

Automated detection of extracellular action potentials from single neurons

This paper introduces an automated method to detect extracellular action potentials from individual neurons, insensitive to waveform changes, enabling high-content screening with MEAs.

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

The paper identifies 6-O-sulfation on heparan sulfate proteoglycans as critical for tau internalization and shows it regulates uptake in multiple cell models.