Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining
Fumiaki Ito, Ziyuan Li, Минахин Леонид Станиславович, Htet A. Khant, Richard T. Pomerantz, Xiaojiang S. Chen
This study presents cryo-EM structures of Pol theta-helicase domain bound to DNA, revealing its conformational changes during microhomology-mediated end joining.
Nature Communications · Apr 19, 2025Peer-reviewedMolecular Biology