Xiaojiang S. Chen

APOBEC3G Splicing Defects in Nonhuman Primate Models Result in Disparate Viral Mutational Profiles Relative to Humans

This study identifies APOBEC3G splicing defects in nonhuman primates that lead to different viral mutation profiles compared to humans.

Structure of full-length APOBEC3B bound to EBV BORF2 reveals coordinated neutralization of a cancer-associated mutator

This study determines the structure of full-length APOBEC3B bound to EBV BORF2, showing how the NTD and CTD domains coordinate to neutralize A3B's mutagenic activity.

Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining

This study presents cryo-EM structures of Pol theta-helicase domain bound to DNA, revealing its conformational changes during microhomology-mediated end joining.

PNAbind: Structure-based prediction of protein-nucleic acid binding using graph neural networks

PNAbind predicts protein-nucleic acid binding using graph neural networks, achieving high accuracy in binding site prediction and discrimination between DNA and RNA specificity.

Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15

This study presents cryoEM structures of SARS-CoV-2 Nsp15 bound to dsRNA, revealing how it recognizes and cleaves poly(U) tracts to evade host immunity.

Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain

This study identifies how AA/GA dinucleotides downstream of target-C sites enhance APOBEC3G DNA editing through structural and biochemical analysis of rhesus macaque A3G.