Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors
Sudha Mishra, Manish Kumar Yadav, Annu Dalal, Manisankar Ganguly, Ravi Yadav, Kazuhiro Sawada, Divyanshu Tiwari, Nabarun Roy, Nilanjana Banerjee, Jenny N. Fung, Jianina Marallag, Cedric S. Cui, Xaria X. Li, John D. Lee, Calvin Aaron Dsouza, , Arun K. Shukla
This study identifies a convergent molecular mechanism and species-specific pharmacology in complement anaphylatoxin receptors through structural and functional analyses of ligand-receptor interactions.
bioRxiv · May 26, 2025 · PreprintBiochemistry