Author

Zhile Wu

Shanghai Normal UniversityORCID 0000-0002-8975-5471Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:experimental assay· 1

Frequent Co-Authors

Guoping ZhaoiD· 1 shared Jin WangiD· 1 shared Lei YiniD· 1 shared Songkuan ZhuangiD· 1 shared Tianshuai Hu· 1 shared Xiaoman Kang· 1 shared Yijian CheniD· 1 shared Yong XuiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperMolecular Biology

Guoping ZhaoORCID

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1 paper

Recent·Most cited

Reversible regulation of Cas12a activities by AcrVA5-mediated acetylation and CobB-mediated deacetylation

Xiaoman Kang, Lei Yin, Songkuan Zhuang, Tianshuai Hu, Zhile Wu, Guoping Zhao, Yijian Chen, Yong Xu, Jin Wang

This study shows that Cas12a activity is reversibly regulated by AcrVA5-mediated acetylation and CobB-mediated deacetylation, revealing a secondary safeguard for bacterial CRISPR defense systems.

Cell Discovery · May 17, 2022Peer-reviewedMolecular Biology