Yong Xu

This study modifies a molecule to create two variants with different target selectivity, showing how small structural changes can control degradation activity.

This study reveals the asymmetric binding of SRC1 to FXR-RXR and the allosteric communication within the complex, providing a structural model for understanding FXR function and its disease implications.

This study develops a CRISPR-Cas12a-based system for rapid and sensitive NAD+ detection using acetylation and CobB reactivation.

This study shows that Cas12a activity is reversibly regulated by AcrVA5-mediated acetylation and CobB-mediated deacetylation, revealing a secondary safeguard for bacterial CRISPR defense systems.