Reconstructing cell histories in space with image-readable base editor recording
Duncan M. Chadly, Kirsten L. Frieda, Chen Gui, Leslie Klock, Martin Tran, Margaret Y Sui, Yodai Takei, Remco Bouckaert, Carlos Lois, Long Cai, Michael B. Elowitz
This paper introduces baseMEMOIR, a method that reconstructs high-resolution cell lineage trees and spatial dynamics using base editing and imaging, achieving 792 bits of memory in embryonic stem cells.
bioRxiv · Jan 3, 2024 · PreprintSynthetic Biology