Author

Kirsten L. Frieda

California Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Carlos LoisiD· 2 shared Long CaiiD· 2 shared Michael B. ElowitziD· 2 shared Alejandro A. GranadosiD· 1 shared Carolina S. Lopes· 1 shared Chee-Huat Linus Eng· 1 shared Chen GuiiD· 1 shared Duncan M. ChadlyiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersSynthetic Biology

Carlos LoisORCID

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Author profile →

3 papers

Recent·Most cited

A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9+ Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive Autoimmunity

Yuqing Wang, Khashayar Afshari, Nazgol‐Sadat Haddadi, Carolina S. Lopes, Chee-Huat Linus Eng, Leah M. Whiteman, Nuria Martinez, Pyae Phyo Kyawe, Ksenia S. Anufrieva, Kevin Wei, Kirsten L. Frieda, Misha A. Rosenbach, Ruth Ann Vleugels, Stefania Gallucci, John E. Harris, , Manuel G. Garber

This study identifies MMP9+ CD14+ myeloid cells as key drivers of UVB-induced IFN-I-driven inflammation in cutaneous lupus and dermatomyositis through a keratinocyte-fibroblast-myeloid circuit.

Nature Immunology · Apr 24, 2026Peer-reviewedImmunology

Reconstructing cell histories in space with image-readable base editor recording

Duncan M. Chadly, Kirsten L. Frieda, Chen Gui, Leslie Klock, Martin Tran, Margaret Y Sui, Yodai Takei, Remco Bouckaert, Carlos Lois, Long Cai, Michael B. Elowitz

This paper introduces baseMEMOIR, a method that reconstructs high-resolution cell lineage trees and spatial dynamics using base editing and imaging, achieving 792 bits of memory in embryonic stem cells.

bioRxiv · Jan 3, 2024 · PreprintSynthetic Biology

Imaging cell lineage with a synthetic digital recording system

Ke-Huan K. Chow, Mark W. Budde, Alejandro A. Granados, Maria Cabrera, Shinae Yoon, Soomin Cho, Ting-Hao Huang, Noushin Koulena, Kirsten L. Frieda, Long Cai, Carlos Lois, Michael B. Elowitz

A new genetic editing system termed intMEMOIR reveals the lineage histories of individual cells directly within their native tissue context.

Science · Apr 9, 2021Peer-reviewedSynthetic Biology