Duncan M. Chadly

This paper introduces LagTag, a method to recover both earlier and endpoint chromatin states in mammalian cells, and applies it to study dynamic chromatin transitions during stem cell differentiation.

This paper introduces a regenerative molecular recording system called hypercascade that enables deep lineage reconstruction by maintaining a constant mutation rate over time.

Synaptic MEMOIR maps individual synapses in neuronal projections using protein barcodes, enabling single-synapse resolution in large brain volumes without high-resolution imaging.

This paper introduces baseMEMOIR, a method that reconstructs high-resolution cell lineage trees and spatial dynamics using base editing and imaging, achieving 792 bits of memory in embryonic stem cells.